The effect of erythropoietin on uterus inflammation during ischemia reperfusion injury in rats

• Published in: Ceská gynekologie Vol. 81; no. 5; p. 342
• Main Authors: Tsompos, C, Panoulis, C, Toutouzas, K, Triantafyllou, A, Zografos, G, Papalois, A
• Format: Journal Article
• Language: English
• Published: Czech Republic 2016
• Subjects: Animals; Antioxidants - pharmacology; Disease Models, Animal; Erythropoietin - pharmacology; Female; Inflammation - drug therapy; Rats, Wistar; Reperfusion Injury - prevention & control; Uterus - blood supply; uterus inflammation reperfusion; erythropoietin; ischemia
• ISSN: 1210-7832

This experiment evaluated the influence of erythropoietin (Epo) in an animal model of uterine ischemia reperfusion using the quoting established protocol. The effects of erythropoietin treatment were evaluated by mean uterus inflammation (UI) lesions. UI lesions were determined at the 60th reperfusion min (for groups A and C) and at the 120th reperfusion min (for groups B and D). Groups A and B received no drugs, whereas rats from groups C and D were administered with erythropoietin. 40 rats of mean mass 247.7 g were employed for the study. Epo administration non-significantly decreased the UI scores [without lesions] by 0.1 [-0.6244129 - 0.4244129] (p = 0.6294)). Reperfusion time kept non-significantly increased the UI scores by [without lesions] 0.15 [-0.60230385 - 0.50230385] (p = 0.5782). Together, Epo administration combined with reperfusion time non-significantly decreased the UI scores by [without lesions] 0.0727273 [-0.3886782 - 0.2432236] (p = 0.6439). Epo administration whether it interacted or not with reperfusion time non-significantly short-term decreased the UI lesions scores. Perhaps, a longer study time than two hours or a higher Epo dose may provide more significant effects.