Fibrolamellar hepatocellular carcinoma with ovarian metastasis - an unusual presentation

• Published in: Romanian journal of morphology and embryology Vol. 58; no. 1; pp. 187 - 192
• Main Authors: Ciurea, Silviu Horia, Matei, Emil, Stănescu, CodruŢ Silvian, Lupescu, Ioana Gabriela, Boroş, Mirela, Herlea, Vlad, Luca, Niculina Ioana, DorobanŢu, Bogdan Mihail
• Format: Journal Article
• Language: English
• Published: Romania 2017
• Subjects: Carcinoma, Hepatocellular - diagnostic imaging; Carcinoma, Hepatocellular - pathology; Fatal Outcome; Female; Humans; Immunohistochemistry; Neoplasm Recurrence, Local - pathology; Ovarian Neoplasms - diagnostic imaging; Ovarian Neoplasms - secondary; Tomography, X-Ray Computed; Young Adult
• ISSN: 1220-0522

Fibrolamellar carcinoma (FLC) has been considered a distinct clinical entity vs. hepatocellular carcinoma, with respect to its epidemiology, etiology, and prognosis. We describe the unusual case of a 23-year-old female patient with FLC and ovarian (Krukenberg) and peritoneal metastases, clinically mimicking an ovarian carcinoma. Multiple recurrences occurred despite initial R0 resection and chemotherapy, requiring surgical treatment. The patient survived five years and died from generalized disease. The particularities of our case are discussed by comparison with the other two similar cases and other date from the literature. To our knowledge, the ovarian involvement encountered in our case is the third case published in literature, being explained by the superficial location of the liver tumor.