Motor impairment and skeletal mineralization in children with cerebral palsy

• Published in: Journal of the Pakistan Medical Association Vol. 67; no. 2; pp. 200 - 203
• Main Authors: Akhter, Noreen, Khan, Atif Ahmed, Ayyub, Aisha
• Format: Journal Article
• Language: English
• Published: Pakistan 01.02.2017
• Subjects: Cerebral Palsy, CP, Bone mineral density, BMD, Dual energy X-ray absorptiometry, DEXA, Lumber vertebra
• ISSN: 0030-9982

To evaluate the bone mineral density and the effect of motor impairment on bone mineral density in children with cerebral palsy. The cross-sectional study was conducted at the Armed Forces Institute of Rehabilitation Medicine, Rawalpindi, Pakistan, from January 2013 to January 2015. Children diagnosed with cerebral palsy were sampled by non-probability purposive sampling from the Cerebral Palsy clinic. On the basis of Gross Motor Function Classification level of motor impairment, the children were divided into mild Cerebral Palsy (level 1 & 2) and moderate to severe Cerebral Palsy (level 3-5) groups. Bone mineral density z-score was measured at lumbar spine with Dual Energy X-Ray Absorptiometry at L1-L4 lumbar vertebra. Data was analysed using SPSS 20. Of the total 108 children selected, 18(16.6%) had to be excluded due to poor nutrition status or deranged serum chemistry, while in 4(3.7%) children Dual Energy X-ray Absorptiometry scan was not done on technical grounds. Of the remaining 86(79.6%) children, 39(45.3%) were males and 47(54.7%) were females. The overall mean age was 6.08±2.89 years and mean bone mineral density z-score was -2.16±0.62. Statistically significant difference was found in bone mineral density z-scores of moderate to severe compared to mild Cerebral Palsy group (p<0.05). Significant difference in bone mineral density z-scores was also found among different levels of Gross Motor Function Classification system of motor impairment (p<0.05). Cerebral Palsy children had low bone mineral density z-score, especially those who were non-ambulatory.