Expression of metallothionein and Ki-67 antigen in GISTs of different grade of malignancy

Metallothioneins (MTs) are low molecular weight proteins (6-7 kDa), which have been shown to regulate zinc ion homeostasis. MTs exert anti-apoptotic and pro-proliferative effect on cancer cells. Overexpression of MT-I and MT-II isoforms has been noted in many malignant tumors, but the role of their...

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Published inAdvances in clinical and experimental medicine : official organ Wroclaw Medical University Vol. 22; no. 4; pp. 513 - 518
Main Authors Puła, Bartosz, Strutyńska-Karpińska, Marta, Markowska-Woyciechowska, Alicja, Jethon, Aleksandra, Wołowiec, Dariusz, Ryś, Janusz, Podhorska-Okołów, Marzena, Grabowski, Krzysztof, Dzięgiel, Piotr
Format Journal Article
LanguageEnglish
Published Poland 01.07.2013
Subjects
Adult
Aged
Aged, 80 and over
Cell Proliferation
Female
Gastrointestinal Stromal Tumors - chemistry
Gastrointestinal Stromal Tumors - pathology
Humans
Immunohistochemistry
Ki-67 Antigen - analysis
Male
Metallothionein - analysis
Middle Aged
Neoplasm Grading
Protein Isoforms
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Summary:Metallothioneins (MTs) are low molecular weight proteins (6-7 kDa), which have been shown to regulate zinc ion homeostasis. MTs exert anti-apoptotic and pro-proliferative effect on cancer cells. Overexpression of MT-I and MT-II isoforms has been noted in many malignant tumors, but the role of their expression in gastrointestinal stromal tumors (GISTs) remains unclear. The aim of the study was to examine the relationship between expression of MT-I/II and K-67 proliferation antigen in a subset of GISTs presenting differential grade of malignancy. The study was conducted using immunohistochemical methods on archival paraffin sections of 34 cases of GISTs. Of those, 17 tumors were classified as benign (GISTB) and 17 tumors as malignant (GISTM). The GISTM cases demonstrated higher MT-I/II expression as compared to the GISTB cases, but not significantly higher (p = 0.08). The GISTM tumors showed significantly higher expression of Ki-67 antigen than the GISTB cases (p = 0.01). MT-I/II and Ki-67 expression positively correlated in GISTBs (r = 0.48, p = 0.0463), but not in GISTMs. The results of this study may point to a potential role of MT-I/II in the proliferation of GIST cells and disease progression.
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ISSN:1899-5276