Protective effects of Nano-elemental selenium against chromium-vi-induced oxidative stress in broiler liver

The valuable role of selenium in mitigation of oxidative stress and heavy metal toxicity is well-known. Thus, the aim of the current study on broiler chickens was to examine whether nano elemental selenium (Nano-Se) supplementation can reduce the effects of chromium VI (K2Cr2O7) toxicity. For this p...

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Bibliographic Details
Published inJournal of biological regulators and homeostatic agents Vol. 32; no. 1; p. 47
Main Authors Xueting, L, Rehman, M U, Zhang, H, Tian, X, Wu, X, Shixue, Mehmood, K, Zhou, D
Format Journal Article
LanguageEnglish
Published Italy 01.01.2018
Subjects
Alanine Transaminase - metabolism
Animals
Aspartate Aminotransferases - metabolism
Avian Proteins - metabolism
Biomarkers - metabolism
Chickens
Chromium - toxicity
gamma-Glutamyltransferase - metabolism
Liver - metabolism
Liver - pathology
Oxidative Stress - drug effects
Oxidoreductases - metabolism
Selenium - pharmacology
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Summary:The valuable role of selenium in mitigation of oxidative stress and heavy metal toxicity is well-known. Thus, the aim of the current study on broiler chickens was to examine whether nano elemental selenium (Nano-Se) supplementation can reduce the effects of chromium VI (K2Cr2O7) toxicity. For this purpose, a total of 150, one-day-old broiler chickens were allotted to five groups with three replicates: control group (standard diet), poisoned group (K2Cr2O7 via drinking water), protection group (K2Cr2O7 + Nano- Se), cure group (K2Cr2O7 for initial 2 weeks and then Nano-Se), and prevention group (opposite to the cure group). The broilers were detected by the activities of marker enzymes and oxidative stress markers including, aspartate aminotransferase (AST), alanine transaminase (ALT), gamma-glutamyl transferase (GGT) and superoxide dismutase (SOD), glutathione peroxidase (GSH-px), malondialdehyde (MDA), respectively. The (K2Cr2O7 administration caused histopathological damage in the liver of the chickens. Moreover, changes in serum biochemical indicators and oxidative stress parameters were also observed. Nano-Se supplementation increased the levels of GSH-px but reduced the activities of SOD, MDA, GGT, ALT and AST in the experimental groups (P less than 0.05). Our results showed that Nano-Se plays a protective role by preventing the oxidative stress induced by the chromium VI in broiler chickens.
ISSN:0393-974X