Clinical and biological heterogeneity in acute respiratory distress syndrome: direct versus indirect lung injury

The acute respiratory distress syndrome (ARDS) is a heterogeneous group of illnesses affecting the pulmonary parenchyma with acute onset bilateral inflammatory pulmonary infiltrates with associated hypoxemia. ARDS occurs after 2 major types of pulmonary injury: direct lung injury affecting the lung...

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Bibliographic Details
Published inClinics in chest medicine Vol. 35; no. 4; p. 639
Main Authors Shaver, Ciara M, Bastarache, Julie A
Format Journal Article
LanguageEnglish
Published United States 01.12.2014
Subjects
Acute Lung Injury - physiopathology
Animals
Disease Models, Animal
Humans
Respiratory Distress Syndrome, Adult - physiopathology
Risk Factors
Acute respiratory distress syndrome
Acute lung injury
Direct lung injury
Indirect lung injury
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Summary:The acute respiratory distress syndrome (ARDS) is a heterogeneous group of illnesses affecting the pulmonary parenchyma with acute onset bilateral inflammatory pulmonary infiltrates with associated hypoxemia. ARDS occurs after 2 major types of pulmonary injury: direct lung injury affecting the lung epithelium or indirect lung injury disrupting the vascular endothelium. Greater understanding of the differences between direct and indirect lung injury may refine the classification of patients with ARDS and lead to development of new therapeutics targeted at specific subpopulations of patients with ARDS.
ISSN:1557-8216
DOI:10.1016/j.ccm.2014.08.004