Metabolic syndrome in subjects with bipolar disorder and major depressive disorder in a current depressive episode: Population-based study: Metabolic syndrome in current depressive episode

• Published in: Journal of psychiatric research Vol. 92; p. 119
• Main Authors: Moreira, Fernanda Pedrotti, Jansen, Karen, Cardoso, Taiane de Azevedo, Mondin, Thaíse Campos, Magalhães, Pedro Vieira da Silva, Kapczinski, Flávio, Souza, Luciano Dias de Mattos, da Silva, Ricardo Azevedo, Oses, Jean Pierre, Wiener, Carolina David
• Format: Journal Article
• Language: English
• Published: England 01.09.2017
• Subjects: Adolescent; Adult; Bipolar Disorder - complications; Bipolar Disorder - epidemiology; Cholesterol - metabolism; Community Health Planning; Cross-Sectional Studies; Depressive Disorder, Major - complications; Depressive Disorder, Major - epidemiology; Female; Glucose - metabolism; Humans; Male; Metabolic Syndrome - epidemiology; Metabolic Syndrome - etiology; Prevalence; Young Adult; Mood disorders; Bipolar disorder; Metabolic syndrome; Major depressive disorder
• ISSN: 1879-1379; 1879-1379
• DOI: 10.1016/j.jpsychires.2017.03.025

To assess the differences in the prevalence of the metabolic syndrome (MetS) and their components in young adults with bipolar disorder (BD) and major depressive disorder (MDD) in a current depressive episode. This was a cross-sectional study with young adults aged 24-30 years old. Depressive episode (bipolar or unipolar) was assessed using the Mini International Neuropsychiatric Interview - Plus version (MINI Plus). The MetS was assessed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III). The sample included 972 subjects with a mean age of 25.81 (±2.17) years. Both BD and MDD patients showed higher prevalence of MetS compared to the population sample (BD = 46.9%, MDD = 35.1%, population = 22.1%, p < 0.001). Higher levels of glucose, total cholesterol and LDL cholesterol, Body Mass Index, low levels of HDL cholesterol, and a higher prevalence of abdominal obesity were observed in both BD and MDD individuals with current depressive episode compared to the general population. Moreover, there was a significant difference on BMI values in the case of BD and MDD subjects (p = 0.016). Metabolic components were significantly associated with the presence of depressive symptoms, independently of the diagnosis.