Hepatic resection for multiple hepatocellular carcinoma less than 5 cm: a prospective comparative study

• Published in: Hepato-gastroenterology Vol. 61; no. 129; p. 173
• Main Authors: Shen, Wei-Feng, Wu, Lu, Dong, Hui, Sui, Cheng-Jun, Dai, Bing-Hua, Shen, Rong-Xi, Yang, Jia-Mei
• Format: Journal Article
• Language: English
• Published: Greece 01.01.2014
• Subjects: Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - surgery; Female; Hepatectomy - methods; Humans; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Multiple Primary - surgery; Prognosis; Prospective Studies; Survival Rate; Treatment Outcome
• ISSN: 0172-6390
• DOI: 10.5754/hge13606

Treatment of multiple hepatocellular carcinoma (HCC) remains a critical issue. In addition, the prognosis and prognostic factors of multiple HCC after hepatic resection are rarely prospectively documented. The clinicopathologic and follow-up data of 81 patients who underwent curative resection of HCC between January 2008 and January 2009 were prospectively collected. Patients were categorized according to the size of the largest tumor: group A (n = 40, two or three HCCs with maximum tumor diameter > 3 cm and < or = 5 cm) and group B (n = 41, two or three HCCs with maximum tumor diameter < or = 3 cm). The two groups were compared for clinicopathologic data and survival results. The 1-, 2-, 3-, and 4-year survival rates of group A were 75.0%, 58.0%, 50.0%, and 44.0%, respectively, while the survival rates of group B were 93.0%, 80.0%, 66.0%, and 47.0%, respectively. The 1-, 2-, 3-, and 4-year disease-free survival rates of group A were 43.0%, 30.0%, 23.0%, and 15.0%, respectively, comparing to 71.0%, 54.0%, 44.0%, and 36.0% in group B, respectively. The median overall cumulative survival time of group A and group B were 36.0 and 44.5 months, respectively (P = 0.322). The median disease-free survival time of group A was 10.0 months and was significantly shorter than that of group B (30.0 months, P = 0.011). Resection may provide comparative survival benefits even for patients with multiple HCCs with maximum tumor diameter > 3 cm and < or = 5 cm.