Impacts on the third line of defense specialized against microbial infection as a result of exposure to gamma-radiation

• Published in: Pakistan journal of pharmaceutical sciences Vol. 28; no. 5 Suppl; pp. 1839 - 1843
• Main Authors: Abd El-Halim, Mohamed Anwar Kassem, Mohamed Sabra, Sherifa Mostafa
• Format: Journal Article
• Language: English
• Published: Pakistan 01.09.2015
• Subjects: Animals; Bacterial Infections - radiotherapy; Blood Cell Count; Dose-Response Relationship, Radiation; Gamma Rays - adverse effects; Granulocytes - radiation effects; Leukocyte Count; Leukocytes - radiation effects; Male; Platelet Count; Rats; Rats, Inbred WKY
• ISSN: 1011-601X

To understand the toxicity and the potential role of gamma-radiation (GR) as a therapeutic tool, the effects of different GR doses on haematological and dimensional properties of rats' blood were investigated in vivo. 60 healthy male Wistar-Kyoto rats were used in this study, and were randomly divided into 5 groups, 4 GR rat groups (1st group was radiated with 5 R, 2nd group 25 Gy; 3rd group with 50 Gy, 4th group with 100 Gy and 5th group was the control). Different haematological and dimensional parameters were measured using the standard haematological technique for complete blood count (CBC). A significant decrease in white blood cells (WBCs) count and lymphocytes (LYM) was observed compared with the control. While a significant increase in monocytes (MON), neutrophils (NEU), basophils (BAS), and eosinophils (EOS) were observed. A non-significant decrease in platelets (PLTs) count was observed with GR compared with the control.