Preventing Cardiogenic Thromboembolism in Cats: Literature Gaps, Rational Recommendations, and Future Therapies

Cardiogenic arterial thromboembolism (CATE) is a devastating complication in cats with cardiomyopathies with significant morbidity and mortality. Despite recent advances in the diagnosis and treatment of CATE, its recurrence and mortality remain high. This highlights the urgent need for a greater un...

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Bibliographic Details
Published inThe Veterinary clinics of North America. Small animal practice
Main Authors Shaverdian, Meg, Li, Ronald H L
Format Journal Article
LanguageEnglish
Published United States 01.11.2023
Subjects
Hypertrophic cardiomyopathy
Immunothrombosis
Thromboprophylaxis
Neutrophil extracellular traps
Platelet priming
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Summary:Cardiogenic arterial thromboembolism (CATE) is a devastating complication in cats with cardiomyopathies with significant morbidity and mortality. Despite recent advances in the diagnosis and treatment of CATE, its recurrence and mortality remain high. This highlights the urgent need for a greater understanding of CATE pathophysiology so that novel diagnostic tests and therapeutics can be developed. This comprehensive review aims to summarize existing literature on pathophysiology, clinical diagnosis, and current recommendations on the prevention and treatment of CATE. It also identifies and describes knowledge gaps and research priorities in the roles of immunothrombosis and procoagulant platelets in the pathogenesis of CATE.
ISSN:1878-1306
DOI:10.1016/j.cvsm.2023.06.002