Postoperative cognitive dysfunction in living liver transplant donors

• Published in: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation Vol. 12 Suppl 1; pp. 81 - 85
• Main Authors: Bucak, Nizamettin, Begeç, Zekine, Erdil, Feray, Toprak, Hüseyin İlksen, Cumurcu, Birgül Elbozan, Demirtaş, Yasemin, Yoloğlu, Saim, Durmuş, Mahmut, Ersoy, Mehmet Özcan
• Format: Journal Article
• Language: English
• Published: Turkey 01.03.2014
• Subjects: Adolescent; Adult; Aged; Attention; Cognition; Cognition Disorders - diagnosis; Cognition Disorders - etiology; Cognition Disorders - physiopathology; Cognition Disorders - psychology; Female; Frontal Lobe - physiopathology; Hepatectomy - adverse effects; Humans; Liver Transplantation - adverse effects; Living Donors - psychology; Male; Middle Aged; Psychiatric Status Rating Scales; Stroop Test; Time Factors; Trail Making Test; Treatment Outcome; Young Adult
• ISSN: 2146-8427
• DOI: 10.6002/ect.25Liver.O13

Postoperative cognitive dysfunction is a serious complication that may be associated with increased mortality. Living-donor liver transplant includes major surgery for the donor. The purpose of this study was to evaluate preoperative and postoperative cognitive function of liver donors in living-donor liver transplant. In 102 patients who had hepatectomy for liver transplant donation, preoperative and postoperative (1 week) neuropsychologic tests were performed including the Trail Making Test, the Stroop effect, score on the Beck Depression Inventory, and the mini-mental state examination. Liver transplant donors had significantly lower mean Trail Making A Test duration and greater mean Trail Making B Test error number after than before surgery. The mean Stroop effect reading durations (black and white reading; reading colored words) were significantly greater after than before surgery; the mean time difference between naming the colors of colored words minus reading colored words, and the error number, were smaller after than before surgery. The mean score on the Beck Depression Inventory and mini-mental state examination score were similar before and after surgery. Mild frontal lobe dysfunction may be present in liver donors at 1 week after surgery, and postoperative attention problems may be experienced by these patients.