Acute generalized exanthematous pustulosis during antituberculosis therapy

Acute generalized exanthematous pustulosis (AGEP) is a significant adverse cutaneous reaction most often induced by drugs and by acute infections. Its clinical hallmark is the sudden onset of multiple, disseminated, non-follicular, sterile pustules on an erythematous background usually arising in in...

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Bibliographic Details
Published inClinica terapeutica Vol. 164; no. 2; p. e137
Main Authors Cantisani, C, Paradisi, A, Richetta, A G, Mattozzi, C, Calvieri, S
Format Journal Article
LanguageEnglish
Published Italy 2013
Subjects
Acute Generalized Exanthematous Pustulosis - etiology
Aged
Antitubercular Agents - adverse effects
Humans
Male
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Summary:Acute generalized exanthematous pustulosis (AGEP) is a significant adverse cutaneous reaction most often induced by drugs and by acute infections. Its clinical hallmark is the sudden onset of multiple, disseminated, non-follicular, sterile pustules on an erythematous background usually arising in intertriginous folds, associated with fever, massive neutrophilia and sometimes eosinophilia. Antitubercular therapy is described as an uncommon cause of AGEP. We report the onset of disseminated non-follicular sterile pustules on an erythematous background in a 68-year-old man receiving a combination of isoniazid, pyrazinamide and rifampicin that may have been the etiologic agents. A thorough history, including a medication history, with clinicopathologic correlation is crucial in patients presenting with acute diffuse pustular lesions.
ISSN:1972-6007
DOI:10.7417/CT.2013.1546