Formulation of chitosan patch incorporating Artocarpus altilis heartwood extract for improving hyperpigmentation

• Published in: Journal of cosmetic science Vol. 68; no. 4; p. 257
• Main Authors: Kwankaew, Jutatip, Phimnuan, Preeyawass, Wanauppathamkul, Sombat, Viyoch, Jarupa
• Format: Journal Article
• Language: English
• Published: United States 01.07.2017
• Subjects: Administration, Topical; Adult; Artocarpus - chemistry; Chitosan - chemistry; Cosmetics - adverse effects; Cosmetics - chemistry; Cosmetics - pharmacology; Female; Humans; Hydrogels - chemistry; Hyperpigmentation - drug therapy; Male; Mannose-Binding Lectins - adverse effects; Mannose-Binding Lectins - chemistry; Mannose-Binding Lectins - pharmacology; Middle Aged; Plant Extracts - adverse effects; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Lectins - adverse effects; Plant Lectins - chemistry; Plant Lectins - pharmacology; Wood - chemistry; Young Adult
• ISSN: 1525-7886

heartwood extract contains the bioactive compound artocarpin which exhibits melanogenesis inhibitory activity. However, the extract has poor solubility which affects the skin permeability of the compound. A chitosan hydrogel patch incorporating heartwood extract was formulated to enhance the delivery of an amount of artocarpin sufficient for depigmenting the skin. The extract was prepared as an o/w microemulsion before blending with an aqueous solution of chitosan. The hydrogel patch was formulated by blending in a 1:1 ratio by weight of 4% w/w chitosan solution and 0.04% w/w extract microemulsion which provides optimal values of the mechanical properties of the patch. The release of artocarpin from the formulated patch (artocarpin content, 0.07 mg/cm ) exhibited two phases; the rapid rate (0-15 min) averaged 0.73 µg/min/mm , and the slow rate (15-240 min) averaged 0.02 µg/min/mm . The formulated patches significantly improved the hyperpigmented area of the subjects after 3 weeks of application. No adverse events were observed. The results indicate that the formulated chitosan hydrogel patch delivers an effective amount of incorporated artocarpin depigmenting action.