Combination of hemodialysis and hemofiltration in severe caffeine intoxication

A 21-year-old man ingested 75g of pure caffeine, in an attempt to commit suicide. This represents 7.5 times the minimal lethal dose. Caffeine, 1,3,7-trimethylxanthine, is the most widely consumed psychoactive compound worldwide. It is mostly found in coffee, tea, energizing drinks and in some drugs....

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Bibliographic Details
Published inNéphrologie & thérapeutique Vol. 13; no. 3; pp. 183 - 187
Main Authors Colin-Benoit, Eugénie, Friolet, Raymond, Rusca, Marco, Teta, Daniel, Gobin, Niels
Format Journal Article
LanguageFrench
Published France 01.05.2017
Subjects
Adult
Caffeine - poisoning
Central Nervous System Stimulants - poisoning
Hemodiafiltration - methods
Humans
Male
Poisoning - diagnosis
Poisoning - therapy
Suicide, Attempted
Treatment Outcome
Hemodialysis
Hémodiafiltration continue
Intoxication
Hémodialyse
Caffeine
Caféine
Continuous hemodiafiltration
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Summary:A 21-year-old man ingested 75g of pure caffeine, in an attempt to commit suicide. This represents 7.5 times the minimal lethal dose. Caffeine, 1,3,7-trimethylxanthine, is the most widely consumed psychoactive compound worldwide. It is mostly found in coffee, tea, energizing drinks and in some drugs. However, it has become really easy to obtain pure caffeine (powder or tablets) on the Internet. Mechanisms of action are dose-dependent. When caffeine overdosing occurs, neurologic, cardiovascular and renal systems are mainly affected. Severe intoxication can be fatal. No antidote is available and treatment is purely symptomatic. Hemoperfusion has previously been carried out in the 1990's to treat patients with caffeine intoxication. Since 2009, hemodialysis and hemofiltration have proposed as well. Our patient was successfully treated with a combination of hemodiafiltration, intermittent and then continuous.
Bibliography:ObjectType-Case Study-2
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ISSN:1872-9177
DOI:10.1016/j.nephro.2016.10.005