Atopic dermatitis physiopathology

Our understanding of the physiopathology of atopic dermatitis has much improved over the recent years. Epidermal barrier alterations are integrated into 2 theories called inside out and outside in. They are related to complex immune abnormalities. Understanding their mechanism makes it possible to f...

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Bibliographic Details
Published inAnnales de dermatologie et de vénéréologie Vol. 144 Suppl 5; pp. VS8 - VS14
Main Author Waton, J
Format Journal Article
LanguageFrench
Published France 01.12.2017
Subjects
Adaptive Immunity
Dermatitis, Atopic - physiopathology
Epidermis - physiopathology
Female
Humans
Immunity, Innate
Microbiota
Pregnancy
Prenatal Exposure Delayed Effects
Smoking - adverse effects
Épigénétique
Microbiota
Immunology
Atopic dermatitis
Immunologie
Microbiote
Epigenetics
Epidermal barrier
Dermatite atopique
Barrière épidermique
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Summary:Our understanding of the physiopathology of atopic dermatitis has much improved over the recent years. Epidermal barrier alterations are integrated into 2 theories called inside out and outside in. They are related to complex immune abnormalities. Understanding their mechanism makes it possible to foresee new therapeutics. Moreover, environmental biodiversity, the diversity of cutaneous microbiota and genetic predispositions in atopic dermatitis lead to a new, more comprehensive theory, « the biodiversity theory », integrating epigenetics.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0151-9638
DOI:10.1016/S0151-9638(18)30086-3