Very High-Power Ablation for Contiguous Pulmonary Vein Isolation: Results From the Randomized POWER PLUS Trial

• Published in: JACC. Clinical electrophysiology Vol. 9; no. 4; pp. 511 - 522
• Main Authors: O'Neill, Louisa, El Haddad, Milad, Berte, Benjamin, Kobza, Richard, Hilfiker, Gabriela, Scherr, Daniel, Manninger, Martin, Wijnmaalen, Adrianus P, Trines, Serge A, Wielandts, Jean-Yves, Gillis, Kris, Lycke, Michelle, De Becker, Benjamin, Tavernier, Rene, Le Polain De Waroux, Jean-Benoit, Knecht, Sebastien, Duytschaever, Mattias
• Format: Journal Article
• Language: English
• Published: United States 01.04.2023
• Subjects: Aged; Atrial Fibrillation - surgery; Catheter Ablation - adverse effects; Catheter Ablation - methods; Esophagus - injuries; Humans; Middle Aged; Prospective Studies; Pulmonary Veins - surgery; Treatment Outcome; atrial fibrillation; safety; efficacy; high-power ablation
• ISSN: 2405-5018
• DOI: 10.1016/j.jacep.2022.10.039

Very high-power, short-duration (90-W/4-second) ablation for pulmonary vein isolation (PVI) may reduce procedural times. However, shorter applications with higher power may impact lesion quality. In this multicenter, randomized controlled trial, the authors compared procedural efficiency, efficacy, and safety of PVI using 90-W/4-second ablation to 35/50-W ablation. Patients with paroxysmal or persistent atrial fibrillation undergoing first-time PVI were randomized to pulmonary vein encirclement with contiguous applications using very high-power, short-duration applications (90 W over 4 seconds) or 35/50-W applications (titrated up to ablation index >550 anteriorly and >400 posteriorly). Prospective endpoints were procedural efficiency (procedure time and first-pass isolation), safety (including esophageal endoscopic evaluation), and 6-month effectiveness using repetitive Holter monitoring. A total of 180 patients were randomized, 90 to the 90-W group (mean age: 64.2 ± 8.9 years) and 90 to the 35/50-W group (mean age: 62.3 ± 10.8 years). Procedural time was shorter in the 90-W group vs the 35/50-W group (70 [IQR: 60-80] minutes vs 75 [IQR: 65-88.3] minutes; P = 0.009). A nonsignificant trend towards lower rates of first-pass isolation was seen in the 90-W group (83.9% vs 90%; P = 0.0852). No major complications were observed in both groups with esophageal injury occurring in 1 patient per group. At 6 months, 17% of patients in the 90-W group vs 15% in the 35/50-W group experienced recurrent arrhythmia (P = 0.681). Contiguous ablation using very high-power, short-duration applications results in a significant but modest reduction in procedure time with similar safety and 6-month efficacy vs a conventional approach. A hybrid approach combining both ablation modalities might be the most optimal strategy. (POWER PLUS [Very High Power Ablation in Patients With Atrial Fibrillation Schedule for a First Pulmonary Vein Isolation]; NCT04784013).