The protective effects of hesperidin pretreatment on kidney and remote organs against renal ischemia-reperfusion injury

As an antioxidant and anti-inflammatory agent, Hesperidin was investigated to prove whether it prevents damage to the kidney and lung tissues of rats undergoing renal ischemia-reperfusion injury. Four groups of rats were set, including eight subjects each as Group 1 (control), Group 2-RIR (renal isc...

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Published inEuropean review for medical and pharmacological sciences Vol. 27; no. 7; p. 2808
Main Authors Karacaer, C, Erdogan, D G, Tanyeli, A, Baylan, H, Eraslan, E, Guler, M C, Polat, E, Comakli, S
Format Journal Article
LanguageEnglish
Published Italy 01.04.2023
Subjects
Animals
Antioxidants - pharmacology
Hesperidin - pharmacology
Hesperidin - therapeutic use
Ischemia
Kidney
Oxidative Stress
Rats
Reperfusion Injury - drug therapy
Reperfusion Injury - prevention & control
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Summary:As an antioxidant and anti-inflammatory agent, Hesperidin was investigated to prove whether it prevents damage to the kidney and lung tissues of rats undergoing renal ischemia-reperfusion injury. Four groups of rats were set, including eight subjects each as Group 1 (control), Group 2-RIR (renal ischemia reperfusion), Groups 3 and 4 as pretreatment groups (50 HES, 100 HES). According to our results, Hesperidin pretreatment improved the biochemical and histopathological parameters in kidney and lung tissues of rats with ischemia-reperfusion injury. Besides, a 100 mg/kg dose of Hesperidin was found to be more beneficial to the rats than 50 mg/kg. The study suggests that Hesperidin is protective against renal and lung tissues of rats that underwent ischemia-reperfusion injury.
ISSN:2284-0729
DOI:10.26355/eurrev_202304_31911