Silence of FIZZ1 by Short Hairpin RNA Inhibits Atherosclerosis

Found in Inflammatory Zone 1 (FIZZ1) protein plays an important enhancive role in inflammation and angiogenesis. This study aims to explore the effects of FIZZ1 on murine atherosclerosis. The murine aortic endothelial cells were treated with an adenoviral vector encoding FIZZ1 short hairpin RNA (Ad-...

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Published inAnnals of clinical and laboratory science Vol. 52; no. 2; pp. 170 - 178
Main Authors Tang, Feng, Yang, Fan, Li, Tong, Yang, Yongyao, Deng, Jiusheng
Format Journal Article
LanguageEnglish
Published United States 01.03.2022
Subjects
Animals
Atherosclerosis - genetics
Endothelial Cells - metabolism
Humans
Inflammation - metabolism
Intercellular Signaling Peptides and Proteins
Mice
Mice, Inbred C57BL
RNA, Small Interfering - genetics
Found in Inflammatory Zone 1
atherosclerosis
aortic endothelial cells
mice
short hairpin RNA
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Summary:Found in Inflammatory Zone 1 (FIZZ1) protein plays an important enhancive role in inflammation and angiogenesis. This study aims to explore the effects of FIZZ1 on murine atherosclerosis. The murine aortic endothelial cells were treated with an adenoviral vector encoding FIZZ1 short hairpin RNA (Ad-shFIZZ1). Murine atherosclerosis model was established with ApoE mice. The effects of FIZZ1 were studied and . Ad-shFIZZ1 treatment suppressed the expression of FIZZ1 and the formation of capillary tube formation . Administration of Ad-shFIZZ1 suppressed FIZZ1-mediated signaling, the growth of endothelial cells and the production of inflammatory molecules in murine aorta , and inhibited the development of atherosclerosis . FIZZ1 played a potent promotive role in atherosclerosis, and could serve as a novel therapeutic target for the treatment of the disease.
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ISSN:1550-8080