Adiponectin and visfatin levels in extremely low birth weight infants; they are also at risk for insulin resistance

The aim of this study was to assess adiponectin, visfatin, HOMA-IR, glucose and triglyceride levels in term, preterm and extremely low birth weight (ELBW) babies. Each of these three groups was subdivided into two groups as small-for-gestational age (SGA), and appropriate-for-gestational age (AGA)....

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Bibliographic Details
Published inEuropean review for medical and pharmacological sciences Vol. 17; no. 4; p. 501
Main Authors Cekmez, F, Canpolat, F E, Pirgon, O, Aydemir, G, Tanju, I A, Genc, F A, Tunc, T, Aydinöz, S, Yildirim, S, Ipcioglu, O M, Sarici, S U
Format Journal Article
LanguageEnglish
Published Italy 01.02.2013
Subjects
Adiponectin - blood
Biomarkers - blood
Blood Glucose - analysis
Case-Control Studies
Cytokines - blood
Gestational Age
Humans
Infant, Extremely Low Birth Weight - blood
Infant, Newborn
Infant, Small for Gestational Age - blood
Insulin - blood
Insulin Resistance
Nicotinamide Phosphoribosyltransferase - blood
Risk
Triglycerides - blood
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Summary:The aim of this study was to assess adiponectin, visfatin, HOMA-IR, glucose and triglyceride levels in term, preterm and extremely low birth weight (ELBW) babies. Each of these three groups was subdivided into two groups as small-for-gestational age (SGA), and appropriate-for-gestational age (AGA). 30 term, 30 preterm and 30 extremely low birth weight infants were included into the study. There was no significant difference in term and preterm infants for serum adiponectin, visfatin, and HOMA-IR levels. There were also no significant differences between term and preterm infants for glucose and triglycerides. The serum visfatin, insulin and HOMA-IR levels (p = 0.001, p = 0.001 and p < 0.05, respectively) were higher in ELBW group than preterm group. Comparing the subgroups as SGA and AGA in all main groups, only in ELBW group there were no significant differences in serum adiponectin, visfatin, HOMA-IR and insulin levels. We suggest that visfatin can be used as an early indicator of insulin resistance. Independent of being SGA, ELBW itself may be a risk factor for insulin resistance. In the follow-up of these babies the risk of obesity, metabolic syndrome and cardiovascular diseases may be increased as in SGA babies.  
ISSN:1128-3602