Chloro, Difluoromethylation and Chloro, Carbomethoxydifluoromethylation: Reaction of Radicals Derived from RfSO2Cl with Unactivated Alkenes under Metal-Free Conditions

Difluoromethyl and carbomethoxydifluoromethyl radicals were generated from their respective sulfonyl chlorides under mild, metal-free conditions leading to efficient atom transfer radical additions (ATRA) to unactivated alkenes to form chloro, difluoromethylated and chloro, carbomethoxydifluoromethy...

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Published inJournal of organic chemistry Vol. 80; no. 2; pp. 1264 - 1268
Main Authors Thomoson, Charles S., Tang, Xiao-Jun, Dolbier, William R.
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 16.01.2015
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
SODIUM TRIFLUOROMETHANESULFINATE
PRACTICAL SYNTHESIS
FLUOROALKYLATION
CHEMISTRY
AMINOTRIFLUOROMETHYLATION
COPPER-CATALYZED ADDITION
NUCLEOPHILIC DIFLUOROMETHYLATION
OXYTRIFLUOROMETHYLATION
EFFICIENT
TRIFLUOROMETHYLATION
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Summary:Difluoromethyl and carbomethoxydifluoromethyl radicals were generated from their respective sulfonyl chlorides under mild, metal-free conditions leading to efficient atom transfer radical additions (ATRA) to unactivated alkenes to form chloro, difluoromethylated and chloro, carbomethoxydifluoromethylated products.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/jo502595g