Idiopathic anaphylaxis yardstick: Practical recommendations for clinical practice

Anaphylaxis is considered idiopathic when there is no known trigger. The signs and symptoms of idiopathic anaphylaxis (IA) are identical to those of anaphylaxis because of a known cause and can include cutaneous, circulatory, respiratory, gastrointestinal, and neurologic symptoms. Idiopathic anaphyl...

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Bibliographic Details
Published inAnnals of allergy, asthma, & immunology Vol. 124; no. 1; pp. 16 - 27
Main Authors Carter, Melody C, Akin, Cem, Castells, Mariana C, Scott, Erin P, Lieberman, Phil
Format Journal Article
LanguageEnglish
Published United States 01.01.2020
Subjects
Adrenal Cortex Hormones - therapeutic use
Anaphylaxis - diagnosis
Anaphylaxis - drug therapy
Diagnosis, Differential
Epinephrine - therapeutic use
Humans
Mastocytosis - diagnosis
Mastocytosis - immunology
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Summary:Anaphylaxis is considered idiopathic when there is no known trigger. The signs and symptoms of idiopathic anaphylaxis (IA) are identical to those of anaphylaxis because of a known cause and can include cutaneous, circulatory, respiratory, gastrointestinal, and neurologic symptoms. Idiopathic anaphylaxis can be a frustrating disease for patients and health care providers. Episodes are unpredictable, and differential diagnosis is challenging. Current anaphylaxis guidelines have little specific guidance regarding differential diagnosis and long-term management of IA. Therefore, the objective of the Idiopathic Anaphylaxis Yardstick is to use published data and the authors' combined clinical experience to provide practical recommendations for the diagnosis and management of patients with IA.
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ISSN:1534-4436
DOI:10.1016/j.anai.2019.08.024