Chronic migraine-cephalgia related to trigeminal artery: a case report of innovative regenerative approach

Persistent trigeminal artery (PTA) originates from the posterior bend or lateral wall of the intra-cavernous carotid artery and is the most common occurring type of remnant primitive fetal arteries. In literature, there is limited number of reports on migraine-cephalgia (MC) associated with coexisti...

Full description

Saved in:
Bibliographic Details
Published inJournal of biological regulators and homeostatic agents Vol. 33; no. 6 Suppl. 2; p. 23
Main Authors Gargiulo Isacco, C, Inchingolo, F, Nguyen, K C D, Ballini, A, Schiffman, M, Aityan, S K, Mortellaro, C, Hong, K Q, Vo, N V, Cantore, S, Dipalma, G, Tran, T C, Goker, F, Del Fabbro, M, Greco Lucchina, A
Format Journal Article
LanguageEnglish
Published Italy 01.11.2019
Subjects
estrogen
migraine-cephalgia
testosterone
human placenta extract
B-nicotinamide adenine dinucleotide
CT-angiography
progesterone
trigeminal nerve
persistent trigeminal artery
Online AccessGet more information

Cover

More Information
Summary:Persistent trigeminal artery (PTA) originates from the posterior bend or lateral wall of the intra-cavernous carotid artery and is the most common occurring type of remnant primitive fetal arteries. In literature, there is limited number of reports on migraine-cephalgia (MC) associated with coexisting PTA. The primitive anastomose arteries that fully belong to the intracranial arterial vascular system are not supposed to perform any supportive functional activity; usually they are subjected to normal biological decay caused by the aging process and metabolic dysfunctions. The hypothesis suggests that these primitive fetal arteries such as PTA may not undergo a fast and structural deterioration but they might be active contributors to a series of mechanisms that can cause a variety of idiopathic complaints. Consequently this would bring a different therapeutic approach other than their surgical removal, which is the accepted option today as a solution for these problems. In this case report, a chronic unilateral MC due to coexisting PTA adjacent to trigeminal nerve is presented. The caliber and location of the PTA was confirmed by a CT-Angiography. The MC treatment was achieved by administration of bio-identical testosterone, human placenta extract (HPE), b-nicotinamide adenine dinucleotide (NADH) and low dose amlopidine.
ISSN:0393-974X