Chiral separation of benzamide antipsychotics and determination of their enantiomers by high performance liquid chromatography

A new method of the chiral separation of three drugs such as sulpiride, amisulpride and mosapride was developed on the chiral stationary phase of amylose-tris-(5-chloro-2-methylphenylcarbamate) (ACMPC) by high performance liquid chromatography. The chromatographic behaviors of enantiomers of the thr...

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Bibliographic Details
Published inSepu Vol. 30; no. 12; p. 1265
Main Authors Wang, Liping, Fan, Huajun, Wu, Kunhong, Peng, Xiaosheng, Jiang, Zitao, Zang, Linquan
Format Journal Article
LanguageChinese
Published China 01.12.2012
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Summary:A new method of the chiral separation of three drugs such as sulpiride, amisulpride and mosapride was developed on the chiral stationary phase of amylose-tris-(5-chloro-2-methylphenylcarbamate) (ACMPC) by high performance liquid chromatography. The chromatographic behaviors of enantiomers of the three drugs were investigated in the mobile phases consisted of ethanol and n-hexane (containing 0.1% (v/v) diethylamine). The chromatographic conditions including the composition of the mobile phase, additives and temperature were further optimized for the chiral separation. The mechanism of racemic resolution for the mentioned drugs is discussed thermodynamically and structurally. The results indicated that these three chiral drugs could be separated on an ACMPC column under the optimum conditions, and their chiral resolutions were improved up to more than 1.5. The chromatographic parameters such as the retention factor kappa, separation factor a are presented, and the thermodynamic functions were calculated for the
ISSN:1000-8713
DOI:10.3724/SP.J.1123.2012.07035