Prevention of Prematurity: Advances and Opportunities

Preterm birth (PTB) rate varies widely and has significant racial and ethnic disparities. Although causal mechanisms are ill understood, socioenvironment, phenotype, and genotype provide insight into pathways for preventing PTB. Data suggest varied response to current medical interventions is explic...

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Bibliographic Details
Published inClinics in perinatology Vol. 45; no. 3; p. 579
Main Authors Govindaswami, Balaji, Jegatheesan, Priya, Nudelman, Matthew, Narasimhan, Sudha Rani
Format Journal Article
LanguageEnglish
Published United States 01.09.2018
Subjects
Preterm prevention clinic
Aspirin
Cerclage
Clindamycin
Progesterone
Preterm birth prevention
Clotrimazole
Nifedipine
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Summary:Preterm birth (PTB) rate varies widely and has significant racial and ethnic disparities. Although causal mechanisms are ill understood, socioenvironment, phenotype, and genotype provide insight into pathways for preventing PTB. Data suggest varied response to current medical interventions is explicable Approved by underlying pharmacogenomics. Currently, prevention focuses on minimizing iatrogenic PTB and risk reduction especially in those with prior PTB using proven medical and public health strategies. In the future, preventive approaches will be based on better understanding of sociodemography, nutrition, lifestyles, and underlying individual genetic and epigenetic variation. Statistical approaches and "big-data" models are critical in future study.
ISSN:1557-9840
DOI:10.1016/j.clp.2018.05.013