Risk factors and evolution of calcium and parathyroid hormone levels in hungry bone syndrome after parthyroidectomy for primary hyperparathyroidism

• Published in: Endocrinologia, diabetes y nutricion Vol. 67; no. 5; pp. 310 - 316
• Main Authors: Guillén Martínez, Alberto José, Smilg Nicolás, Clara, Moraleda Deleito, Javier, Guillén Martínez, Sergio, García-Purriños García, Francisco
• Format: Journal Article
• Language: English; Spanish
• Published: Spain 01.05.2020
• Subjects: Hiperparatiroidismo; Primario; Síndrome de hueso hambriento; Hungry bone syndrome; Primary; Parathyroidectomy; Paratiroidectomía; Hyperparathyroidism
• ISSN: 2530-0172; 2530-0180
• DOI: 10.1016/j.endinu.2019.05.011

Hungry bone syndrome (HBS) is a complication occurring after parathyroid surgery that can cause severe and prolonged hypocalcemia. The study objective was to know the risk factors for HBS after surgery for primary hyperparathyroidism and its relationship with serum calcium and parathyroid hormone levels. A case-control, observational, analytical study was conducted in patients who had undergone surgery for primary hyperparathyroidism in the past 10 years (2007-2016). Changes over time in serum calcium and PTH levels and the general characteristics of patients were analyzed. The incidence rate of HBS in our series was 12.2%. HBS was found to be significantly associated to thyroid surgery during the surgical procedure itself (adjusted odds ratio [aOR]=17.241), to age older than 68 years (aOR=6.666), and to lesions greater than 1.7cm (aOR=7.165). A statistically significant relationship was seen between presence of HBS and corrected serum calcium levels higher than the mean the day after surgery and one week and 3 months later, and also with PTH levels higher than the mean before, during, and one day after surgery. In our series, independent risk factors for development of HBS included patient age, lesion size, and whether or not the procedure was accompanied by thyroid surgery, which requires closer monitoring of mineral metabolism during the perioperative period.