Microglia--performers of the 21st century

At the frontier between immunology and neuroscience, microglia, the enigmatic macrophages of the brain, have generated, in recent years, increasing interest. In response to even minor pathological changes in the brain, these extremely versatile glial cells occasionally enter in an over-activating st...

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Published inRomanian journal of morphology and embryology Vol. 55; no. 3; pp. 745 - 765
Main Authors Atallah, Nidal, Vasiu, Renata, Boşca, Adina Bianca, Creţu, Denisa Ioana, Georgiu, Carmen, Constantin, Anne Marie, Sovrea, Alina Simona
Format Journal Article
LanguageEnglish
Published Romania 2014
Subjects
Animals
Cell Communication
Disease
Disease Models, Animal
Fetus - cytology
Humans
Immunophenotyping
Microglia - pathology
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Summary:At the frontier between immunology and neuroscience, microglia, the enigmatic macrophages of the brain, have generated, in recent years, increasing interest. In response to even minor pathological changes in the brain, these extremely versatile glial cells occasionally enter in an over-activating state and produce pro-inflammatory cytokines and free radicals, thereby contributing directly to neuroinflammation and various brain disorders. This review provides an analysis of the latest developments in the microglia field, considering the important new research that illustrate their involvement in brain related diseases.
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ISSN:1220-0522