Peripartum cardiomyopathy and familial dilated Cardiomyopathy: a tale of two cases

Peripartum cardiomyopathy (PPCM) is a form of pregnancyrelated heart failure that is associated with considerable morbidity and mortality. Most patients present with acute postpartal heart failure that otherwise resembles the clinical presentation of dilated cardiomyopathy (DCM). There is increasing...

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Bibliographic Details
Published inCardiovascular journal of South Africa Vol. 24; no. 5; p. e4
Main Authors Tibazarwa, K, Sliwa, K, Wonkam, A, Mayosi, B M
Format Journal Article
LanguageEnglish
Published South Africa 23.06.2013
Subjects
Adult
Asymptomatic Diseases
Cardiomyopathy, Dilated - diagnosis
Cardiomyopathy, Dilated - genetics
Chromosome Disorders
Diagnosis, Differential
Fatal Outcome
Female
Genes, Dominant
Genome-Wide Association Study
Humans
Mutation - genetics
Neovascularization, Physiologic - genetics
Pedigree
Peptide Fragments - genetics
Peripartum Period
Pregnancy
Pregnancy Complications, Cardiovascular - diagnosis
Pregnancy Complications, Cardiovascular - genetics
Prolactin - genetics
Young Adult
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Summary:Peripartum cardiomyopathy (PPCM) is a form of pregnancyrelated heart failure that is associated with considerable morbidity and mortality. Most patients present with acute postpartal heart failure that otherwise resembles the clinical presentation of dilated cardiomyopathy (DCM). There is increasing recognition that PPCM may be due to genetic factors in a significant proportion of cases. There is evidence that at least 7% of cases of PPCM may be part of the spectrum of familial DCM. We report on two cases of PPCM, with relatives demonstrating familial DCM, both patients displaying autosomal dominant patterns of inheritance, and showing severe cardiomyopathy among proband and affected relatives. Family screening for familial DCM should be indicated in all cases of unexplained PPCM.
ISSN:1680-0745
DOI:10.5830/CVJA-2013-027