Explore the therapeutic potential and bioevaluation of giloy leaves (Tinospora cordifolia) powder for the management of type 2 diabetes

• Published in: Pakistan journal of pharmaceutical sciences Vol. 35; no. 6(Special); pp. 1799 - 1803
• Main Authors: Ghafoor, Abdul, Ehtasham, Muhammad, Fatima, Tahira, Ameen, Ayesha, Afroz, Nighat, Mehmood, Ahad, Shabbir, Rida, Hassan, Ali
• Format: Journal Article
• Language: English
• Published: Pakistan 01.11.2022
• Subjects: Blood Glucose; Diabetes Mellitus, Type 2 - drug therapy; Glycated Hemoglobin; Humans; Powders; Tinospora
• ISSN: 1011-601X
• DOI: 10.36721/PJPS.2022.35.6.SP.1799-1803.1

Giloy (Tinospora cordifolia) is an important Ayurvedic medication. Numerous illnesses, including general senility, fever, diabetes, dyspepsia, urinary infections, jaundice and skin conditions are treated with it. The biological description and chemical components of cordifolia are critically reviewed in this essay, with a focus on its ayurvedic properties and pharmaceutical applications. The goal of the current study was to investigate the chemical, phytochemical and mineral profile and anti-diabetic potential of giloy leaves powder. The results showed that the moisture content was 6.2%, ash content was 13.12%, crude protein was 17.27% and fiber was 5.5%. While in mineral analysis, sodium was 22.12±1.78, magnesium was 15.78±1.70, calcium was 9.78±1.27, potassium was 32.24±1.40, iron was 8.37±1.078 and zinc was 4.87±0.89. Furthermore, total phenolic content was 156.78±1.18 and total flavonoid content was 45.78±0.57. Afterwards, the anti-diabetic potential was analyzed by givingthe giloy leaves powder to human experimental group G1 and G2 at adose of 400mg/kg and 800mg/kg, respectively. The effect of giloy leaves powder on diabetes patients' blood sugar levels was monitored every seventh day for 2 months and HbA1c tests were done initially and after 2 months. Random blood sugar and HbA1c were significant in ANOVA.