Is there a rationale for an anesthesiologist's role against cancer recurrence?

Growth of tumors can accelerate during the peri-operative period. Accordingly, early relapse of cancer occurs in some patients during the first two postoperative years. Temporal and biologic analyses of cancer pathophysiology suggest a link between peri-operative pathophysiological changes and accel...

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Published inActa anaesthesiologica belgica Vol. 64; no. 1; pp. 15 - 24
Main Authors Forget, P, Coulie, P G, Retsky, M, Demicheli, R, Machiels, J P, De Kock, M
Format Journal Article
LanguageEnglish
Published Belgium 01.01.2013
Subjects
Anesthesiology - methods
Anesthesiology - trends
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Humans
Inflammation - complications
Inflammation - prevention & control
Neoplasms - complications
Neoplasms - prevention & control
Physician's Role
Secondary Prevention
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Summary:Growth of tumors can accelerate during the peri-operative period. Accordingly, early relapse of cancer occurs in some patients during the first two postoperative years. Temporal and biologic analyses of cancer pathophysiology suggest a link between peri-operative pathophysiological changes and acceleration of tumor growth. Understanding the role of inflammation and its consequences (i.e., immune response, growth factors, dissemination of tumor cells) could lead to define a role of anesthesiologists in reducing cancer recurrence following surgery. We argue for peri-operative pharmacological interventions to reduce cancer relapse, with a focus on non-steroidal anti-inflammatory drugs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0001-5164