Use of murine models for the study of obstructive sleep apnea syndrome in Down syndrome

Down syndrome (DS), or trisomy 21, is a genetic disorder caused by the presence of an extra copy of chromosome 21, leading to various characteristic physical features as well as developmental and cognitive delays. Obstructive sleep apnea syndrome (OSAS) is a common disorder in both adult and pediatr...

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Published inRevue des maladies respiratoires Vol. 41; no. 4; p. 279
Main Authors Moreau, M, Madani, A, Dard, R, Bourgeois, T, d'Ortho, M-P, Delclaux, C, Janel, N, Matrot, B
Format Journal Article
LanguageFrench
Published France 01.04.2024
Subjects
Adult
Animals
Child
Continuous Positive Airway Pressure
Disease Models, Animal
Down Syndrome - complications
Humans
Mice
Sleep Apnea, Obstructive - complications
Sleep Apnea, Obstructive - epidemiology
Obstructive sleep apnea syndrome
Syndrome d’apnées obstructives du sommeil
Down syndrome
Modèles murins
Murine models
Syndrome de Down
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Summary:Down syndrome (DS), or trisomy 21, is a genetic disorder caused by the presence of an extra copy of chromosome 21, leading to various characteristic physical features as well as developmental and cognitive delays. Obstructive sleep apnea syndrome (OSAS) is a common disorder in both adult and pediatric patients with DS. Several characteristics of DS may contribute to the development or worsening of OSAS. Numerous murine models of DS exist. A number of studies have explored apneas and the risk of upper airway obstruction in these models, but up until now, only in adulthood.
ISSN:1776-2588
DOI:10.1016/j.rmr.2024.02.010