Curcumin for the Treatment of Glioblastoma

Glioblastoma multiforme is a highly aggressive primary cancer of the brain associated with a poor prognosis. Modest increases in survival can sometimes be achieved with the use of temozolomide and radiation therapy after surgery, but second-line therapy after recurrence has a limited efficacy. Curcu...

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Bibliographic Details
Published inAnticancer research Vol. 35; no. 12; pp. 6373 - 6378
Main Authors Sordillo, Laura A, Sordillo, Peter P, Helson, Lawrence
Format Journal Article
LanguageEnglish
Published Greece 01.12.2015
Subjects
Blood-Brain Barrier
Curcumin - administration & dosage
Curcumin - pharmacology
Curcumin - therapeutic use
Drug Therapy, Combination - methods
Glioblastoma - drug therapy
Glioblastoma - mortality
Humans
Prognosis
Survival Rate
lipophilic agent
ceramide
blood–brain barrier
review
Glioblastoma
combination chemotherapy
cancer stem cells
lomustine
curcumin
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Summary:Glioblastoma multiforme is a highly aggressive primary cancer of the brain associated with a poor prognosis. Modest increases in survival can sometimes be achieved with the use of temozolomide and radiation therapy after surgery, but second-line therapy after recurrence has a limited efficacy. Curcumin has demonstrated promising results against this form of cancer in experimental models. The reported activity of curcumin against cancer stem cells, a major cause of glioblastoma resistance to therapy, and its ability to augment the apoptotic effects of ceramides, suggest it would have a synergistic effect with cytotoxic chemotherapy agents currently used in second-line therapy, such as lomustine.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1791-7530