Frequency of human papillomavirus infection in patients with gastrointestinal cancer

• Published in: Revista de Gastroenterología de México (English Edition) Vol. 83; no. 3; pp. 253 - 258
• Main Authors: Roesch-Dietlen, F, Cano-Contreras, A D, Sánchez-Maza, Y J, Espinosa-González, J M, Vázquez-Prieto, M Á, Valdés-de la O, E J, Díaz-Roesch, F, Carrasco-Arroniz, M Á, Cruz-Palacios, A, Grube-Pagola, P, Sumoza-Toledo, A, Vivanco-Cid, H, Mellado-Sánchez, G, Meixueiro-Daza, A, Silva-Cañetas, C S, Carrillo-Toledo, M G, Lagunes-Torres, R, Amieva-Balmori, M, Gómez-Castaño, P C, Reyes-Huerta, J U, Remes-Troche, J M
• Format: Journal Article
• Language: English; Spanish
• Published: Mexico 01.07.2018
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - epidemiology; Female; Gastrointestinal Neoplasms - complications; Gastrointestinal Neoplasms - epidemiology; Humans; Male; Mexico - epidemiology; Middle Aged; Papillomaviridae; Papillomavirus Infections - complications; Papillomavirus Infections - epidemiology; Prospective Studies; Risk Factors; Sexual Behavior; Frecuencia; Cáncer del aparato digestivo; Virus del papiloma humano; Frequency; Human papillomavirus; Cancer of the digestive tract
• ISSN: 0375-0906; 2255-534X
• DOI: 10.1016/j.rgmx.2017.09.003

Cancer is the result of the interaction of genetic and environmental factors. It has recently been related to viral infections, one of which is human papillomavirus. The aim of the present study was to describe the frequency of human papillomavirus infection in patients with digestive system cancers. A prospective, multicenter, observational study was conducted on patients with gastrointestinal cancer at 2public healthcare institutes in Veracruz. Two tumor samples were taken, one for histologic study and the other for DNA determination of human papillomavirus and its genotypes. Anthropometric variables, risk factors, sexual habits, tumor location, and histologic type of the cancer were analyzed. Absolute and relative frequencies were determined using the SPSS version 24.0 program. Fifty-three patients were studied. They had gastrointestinal cancer located in: the colon (62.26%), stomach (18.87%), esophagus (7.55%), rectum (7.55%), and small bowel (3.77%). Human papillomavirus was identified in 11.32% of the patients, 66.7% of which corresponded to squamous cell carcinoma and 33.3% to adenocarcinoma. Only genotype 18 was identified. Mean patient age was 61.8±15.2 years, 56.60% of the patients were men, and 43.40% were women. A total of 15.8% of the patients had a family history of cancer and 31.6% had a personal history of the disease, 38.6% were tobacco smokers, and 61.4% consumed alcohol. Regarding sex, 5.3% of the patients said they were homosexual, 3.5% were bisexual, 29.8% engaged in oral sex, and 24.6% in anal sex. Our study showed that human papillomavirus infection was a risk factor for the development of gastrointestinal cancer, especially of squamous cell origin.