Polycyclic aromatic hydrocarbon-induced oxidative stress, antioxidant capacity, and the risk of lung cancer: a pilot nested case-control study

We conducted a pilot nested case-control study to prospectively evaluate the effects of polycyclic aromatic hydrocarbons (PAH) exposure, antioxidant capacity, and oxidative stress on lung carcinogenesis. Thirty-five patients with lung cancer and 140 age- and sex-matched controls were selected from a...

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Published inAnticancer research Vol. 33; no. 8; p. 3089
Main Authors Eom, Sang-Yong, Yim, Dong-Hyuk, Moon, Sun In, Youn, Jong-Woo, Kwon, Hyo-Jin, Oh, Hyeong Chan, Yang, Jae Jeong, Park, Sue K, Yoo, Keun-Young, Kim, Hyeong Su, Lee, Kun-Sei, Chang, Soung-Hoon, Kim, Yong-Dae, Kang, Jong-Won, Kim, Heon
Format Journal Article
LanguageEnglish
Published Greece 01.08.2013
Subjects
Aged
Antioxidants - metabolism
Biomarkers, Tumor - urine
Case-Control Studies
Confidence Intervals
Female
Humans
Linear Models
Lung Neoplasms - urine
Male
Odds Ratio
Oxidative Stress
Pilot Projects
Polycyclic Aromatic Hydrocarbons - urine
Risk Factors
Statistics, Nonparametric
lung cancer
antioxidant capacity
Polycyclic aromatic hydrocarbon
cotinine
8-hydroxydeoxyguanosine
thiobarbituric acid
1-hydroxypyrene
nested case–control study
2-naphthol
oxidative stress
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Summary:We conducted a pilot nested case-control study to prospectively evaluate the effects of polycyclic aromatic hydrocarbons (PAH) exposure, antioxidant capacity, and oxidative stress on lung carcinogenesis. Thirty-five patients with lung cancer and 140 age- and sex-matched controls were selected from a sub-cohort of the Korean Multi-center Cancer Cohort. PAH metabolites (1-hydroxypyrene and 2-naphthol), oxidative stress markers, and total antioxidant capacity (TAC) were assessed using urine samples collected at baseline. The levels of urinary PAH metabolites and oxidative stress were not different between cases and controls. Urinary 1-hydroxypyrene and 2-naphthol levels were significantly associated with urinary oxidative stress markers only in lung cancer cases. Individuals with low urinary TAC and high urinary oxidative stress levels had significantly higher risk of lung cancer compared to those with high urinary TAC and low urinary oxidative stress levels. Oxidative stress induced by PAH exposure and TAC may be important determinants for the susceptibility to lung cancer.
ISSN:1791-7530