Peripartum Cardiomyopathy: Progress in Understanding the Etiology, Management, and Prognosis

Occurring in approximately 1 in 1000 live births in the United States, peripartum cardiomyopathy (PPCM) is characterized by left ventricular ejection fraction reduced to less than 45% near the end of pregnancy or within the first 5 months after delivery. Although the cause of PPCM remains unclear, i...

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Bibliographic Details
Published inHeart failure clinics Vol. 15; no. 1; p. 29
Main Authors Lindley, Kathryn J, Verma, Amanda K, Blauwet, Lori A
Format Journal Article
LanguageEnglish
Published United States 01.01.2019
Subjects
Cardiomyopathies - diagnosis
Cardiomyopathies - etiology
Cardiomyopathies - therapy
Disease Management
Female
Humans
Pregnancy
Pregnancy Complications, Cardiovascular - diagnosis
Pregnancy Complications, Cardiovascular - therapy
Prognosis
Puerperal Disorders - diagnosis
Puerperal Disorders - etiology
Puerperal Disorders - therapy
Ventricular Dysfunction, Left - diagnosis
Heart failure
Pregnancy
Peripartum cardiomyopathy
Prognosis
Diagnosis
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Summary:Occurring in approximately 1 in 1000 live births in the United States, peripartum cardiomyopathy (PPCM) is characterized by left ventricular ejection fraction reduced to less than 45% near the end of pregnancy or within the first 5 months after delivery. Although the cause of PPCM remains unclear, increasing evidence supports a complex interaction of genetic and environmental factors contributing to angiogenic imbalance, which may lead to myocardial dysfunction in a susceptible woman. This article reviews the progress that has been made regarding understanding of the cause, management, and natural history of PPCM.
ISSN:1551-7136
DOI:10.1016/j.hfc.2018.08.004