Paracrine properties of Mesenchymal Stromal Cells

Mesenchymal stromal cells are multipotent cells found in a large number of adult tissues. Their ability to participate in the repair of these damaged tissues is the origin of the enthusiasm that they elicit in the field of cell therapy. It gradually became apparent that their ability to change a pat...

Full description

Saved in:
Bibliographic Details
Published inBulletin de l'Académie nationale de médecine Vol. 199; no. 4-5; p. 501
Main Authors Peltzer, Juliette, Lund, Kyle, Lataillade, Jean-Jacques
Format Journal Article
LanguageFrench
Published Netherlands 01.04.2015
Subjects
Adult
Cell Communication - physiology
Exosomes - secretion
Humans
Immunologic Factors - pharmacology
Immunologic Factors - secretion
Mesenchymal Stromal Cells - physiology
Paracrine Communication - physiology
Online AccessGet more information

Cover

More Information
Summary:Mesenchymal stromal cells are multipotent cells found in a large number of adult tissues. Their ability to participate in the repair of these damaged tissues is the origin of the enthusiasm that they elicit in the field of cell therapy. It gradually became apparent that their ability to change a pathological environment is more related to their ability to modulate the behavior of other cell types than their capacity of diferentiation. Recent years have expanded the scope of our knowledge about their way of communication with their environment but also the amount of information that they receive from this environment. In this brief review, we will present some of the mechanisms by which MSCs can communicate remotely with other cell types and how it currently appears possible to direct the secretion pattern of these cells.
ISSN:0001-4079
DOI:10.1016/S0001-4079(19)30923-9