Evaluation of chemical characterization and antihyperlipidemic potential of orange peel powder (Citrus sinensis) in male human subjects

• Published in: Pakistan journal of pharmaceutical sciences Vol. 36; no. 2(Special); p. 613
• Main Authors: Gul, Jawaria, Usman Tariq, Muhammad, Hussain, Sakina, Shabbir, Hasnat, Tahir, Samreen, Zahid, Awais, Shabir Memon, Fawad, Chen, Tse-Wei, Musaed Almutairi, Saeedah, S Elshikh, Mohamed
• Format: Journal Article
• Language: English
• Published: Pakistan 01.03.2023
• Subjects: Capsules; Citrus - chemistry; Citrus sinensis - chemistry; Flavonoids; Humans; Hyperlipidemias - drug therapy; Hypolipidemic Agents - pharmacology; Hypolipidemic Agents - therapeutic use; Lipids; Male; Phenols; Powders
• ISSN: 1011-601X
• DOI: 10.36721/PJPS.2023.36.2.SP.613-617.1

Citrus sinensis is an important member of the genus Citrus which contains phenolic compounds and bioflavonoids which have antihyperlipidemic and antiatherogenic effects. It also has the potential to reduce oxidative stress. To investigate the antihyperlipidemic effect of orange peel powder was encapsulated and analyzed in hyperlipidemic patients. Results showed that it contains moisture (12.2%), ash content (7.9%), crude fat (0.78%), crude protein (12.37%) and crude fiber (13.2%). Total phenolic content and total flavonoid content were observed as 163.17 mg and 17.23mg in quercetin equivalent per gram a dry weight basis. Furthermore, the Orange peel powder was given in the form of medicinal capsules to hyperlipidemia male subjects. The experimental groups (G and G ) were given orange peel powder in capsules 400mg/d to the G group and 800mg/d to the G group for the time of 45 days. The serum lipid profile of patients was measured before and after the experimental trial. The result showed that G1 and G2 showed a decrease in plasma lipid parameters and increased high-density lipoprotein content in blood substantially as compared to G . Thus, it was concluded from the results that orange peel powder depicts a significant impact on treating hyperlipidemia.