Relationship between bone mineral density, weight, and estrogen levels in pre and postmenopausal women

Bone loss in postmenopausal women is mainly due to estrogen deficiency affecting the balance between osteoclast resorption and bone formation controlled by osteoblasts. To determine the relationship between bone mineral density (BMD) in pre and postmenopausal Caucasian women, and estrogen levels. Cr...

Full description

Saved in:
Bibliographic Details
Published inRevista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi Vol. 116; no. 4; p. 946
Main Authors Corina, Morcov, Vulpoi, Carmen, Brănişteanu, D
Format Journal Article
LanguageEnglish
Published Romania 01.10.2012
Subjects
Absorptiometry, Photon
Biomarkers - blood
Body Composition
Body Mass Index
Body Weight
Bone Density
Cross-Sectional Studies
Estrogens - blood
Female
Humans
Middle Aged
Obesity - complications
Osteoporosis, Postmenopausal - blood
Osteoporosis, Postmenopausal - diagnosis
Osteoporosis, Postmenopausal - epidemiology
Osteoporosis, Postmenopausal - etiology
Overweight - complications
Postmenopause
Premenopause
Prevalence
Risk Factors
Romania - epidemiology
Romania
Online AccessGet more information

Cover

More Information
Summary:Bone loss in postmenopausal women is mainly due to estrogen deficiency affecting the balance between osteoclast resorption and bone formation controlled by osteoblasts. To determine the relationship between bone mineral density (BMD) in pre and postmenopausal Caucasian women, and estrogen levels. Cross-sectional study including six groups of 8 to 15 pre- and postmenopausal healthy volunteers with different weights, body mass index (BMI) (normal or underweight < 25 kg/m2, overweight 25-30 kg/m2, and obese > 30 kg/m2), not exposed to antiosteoporotic therapy. Lumbar bone mineral density (BMD) and body composition (BC) were evaluated by dual X ray absorptiometry (DXA, Hologic), while serum estradiol and estrone were measured by ELISA. BMD in postmenopausal women is lower than in premenopausal women irrespective of body weight (p<0.05). Estradiol and estrone are positively correlate with bone mass in premenopausal women, but not in postmenopausal women (R2 0.3209, R2 0.2579, respectively). It is very important to identify the risk factors for osteoporosis, especially in postmenopausal women, as we will show that aromatization of androgens into estrogens in adipose tissue appears not to have a significant role in postmenopausal women bone protection. Key-
ISSN:0048-7848