Case-control study of obstetrical outcomes of conisation

• Published in: Journal de gynecologie, obstetrique et biologie de la reproduction Vol. 45; no. 2; p. 192
• Main Authors: Brie, C, Turck, M, Cheret, A, Morello, R, Benoist, G, Dreyfus, M
• Format: Journal Article
• Language: French
• Published: France 01.02.2016
• Subjects: Adult; Birth Weight - physiology; Case-Control Studies; Cervical Intraepithelial Neoplasia - epidemiology; Cervical Intraepithelial Neoplasia - rehabilitation; Cervical Intraepithelial Neoplasia - surgery; Conization - adverse effects; Conization - statistics & numerical data; Female; Fetal Membranes, Premature Rupture - epidemiology; Fetal Membranes, Premature Rupture - etiology; Humans; Infant, Newborn; Obstetric Labor, Premature - epidemiology; Obstetric Labor, Premature - etiology; Pregnancy; Pregnancy Complications - epidemiology; Pregnancy Complications - etiology; Pregnancy Outcome - epidemiology; Premature Birth - epidemiology; Premature Birth - etiology; Retrospective Studies; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - rehabilitation; Uterine Cervical Neoplasms - surgery; Young Adult; Pregnancy; Grossesse; Conization; Preterm birth; Rupture prématurée des membranes; Premature rupture of membranes; Conisation; Accouchement prématuré
• ISSN: 1773-0430
• DOI: 10.1016/j.jgyn.2015.07.005

Evaluate the obstetrical outcomes in the case of women with a history of conization. Determine the role of the cone length in the obstetrical issue. Retrospective case-control study including the patients (n=39) who had undergone a conization in a university hospital between January 2002 and January 2012. The obstetrical outcomes have been compared to those from a control group (n=78). Into the exposed group the obstetrical outcomes has been compared based on the cone length. Thirty-one patients delivered after a conization (39 deliveries). The obstetrical outcomes have been significantly increased in the exposed group: preterm delivery before 37 weeks gestation (25.6% vs 7.7%, P=0.01), before 32 weeks gestation (15.4% vs 1.3%, P=0.005) and between 28 weeks gestation (10.2% vs 0%, P=0.01), premature onset of labor before 32 weeks gestation (12.8% vs 1.3%, P=0.01) and before 28 weeks gestation (12.8% vs 0%, P=0.01) and preterm premature rupture of membranes before 37 weeks gestation (20.5% vs 1.3%, P<0.001). There was no significant difference for a length cone more than 1.5cm. Our study showed that a history of conization is an obstetrical risk factor to consider in the management of a subsequent pregnancy.