The History of Biomarkers: How Far Have We Come?

Sepsis is one of the oldest and most elusive syndromes in medicine that is still incompletely understood. Biomarkers may help to transform sepsis from a physiologic syndrome to a group of distinct biochemical disorders. This will help to differentiate between systemic inflammation of infectious and...

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Bibliographic Details
Published inCritical care clinics Vol. 36; no. 1; p. 1
Main Authors Lachmann, Gunnar, Reinhart, Konrad
Format Journal Article
LanguageEnglish
Published United States 01.01.2020
Subjects
Anti-Infective Agents - history
Anti-Infective Agents - therapeutic use
Biological Monitoring - history
Biological Monitoring - methods
Biomarkers - blood
History, 20th Century
History, 21st Century
Humans
Predictive Value of Tests
Sepsis - blood
Sepsis - diagnosis
Sepsis - drug therapy
History
Sepsis
Biomarker
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Summary:Sepsis is one of the oldest and most elusive syndromes in medicine that is still incompletely understood. Biomarkers may help to transform sepsis from a physiologic syndrome to a group of distinct biochemical disorders. This will help to differentiate between systemic inflammation of infectious and noninfectious origin and aid therapeutic decision making, hence improve the prognosis for patients, guide antimicrobial therapy, and foster the development of novel adjunctive sepsis therapies. To reach this goal requires increased systematic investigation that includes twenty-first century scientific approaches and technologies and appropriate clinical evaluation.
ISSN:1557-8232
DOI:10.1016/j.ccc.2019.08.001