Optical Analysis of the Interaction of Mercaptan Derivatives of Nanogold Particles with Carcinoembryonic Antigen

• Published in: Guang pu xue yu guang pu fen xi Vol. 36; no. 2; p. 478
• Main Authors: Zeng, Hong-juan, Zhao, Ran-lin, Wang, De-shun, Li, Cai-xia, Liu, Yi-yao
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2016
• Subjects: Carcinoembryonic Antigen - chemistry; Gold; Humans; Metal Nanoparticles; Sulfhydryl Compounds - chemistry
• ISSN: 1000-0593
• DOI: 10.3964/j.issn.1000-0593(2016)02-0478-04

Gold nanoparticles (AuNPs) have been the subject of intense research for use in biomedicine over the past couple of decades. AuNPs, also referred to as colloidal gold, possess some astounding optical and physical properties that have earned them a prime spot among the new promising tools for medical applications. Today, AuNPs are offered to provide the clinical laboratory with more sensitive, faster, and simpler assays, which are also cost-effective. AuNPs can be used to develop point-of- care tests and novel testing strategies such as in drug targeting, disease detection, molecular recognition, and biological labels. The typical structure of AuNPs is spherical nano-sized gold particles, but they can also be composed of a thin gold shell surrounding a dielectric core, such as silica (gold nanoshells). their size range from 0.8 to 250 nm and are characterized by high absorption coefficients. AuNPs have some unique optical properties, such as enhanced absorption and scattering, where the absorption cross-sectio