The diagnostic value of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase measurement in the sera of patients with endometrial cancer

• Published in: Anticancer research Vol. 33; no. 9; pp. 3725 - 3730
• Main Authors: Orywal, Karolina, Jelski, Wojciech, Zdrodowski, Michał, Szmitkowski, Maciej
• Format: Journal Article
• Language: English
• Published: Greece 01.09.2013
• Subjects: Adult; Aged; Aged, 80 and over; Alcohol Dehydrogenase - blood; Aldehyde Dehydrogenase - blood; Biomarkers, Tumor - blood; Case-Control Studies; Endometrial Neoplasms - blood; Endometrial Neoplasms - enzymology; Female; Humans; Isoenzymes - blood; Middle Aged; Spectrometry, Fluorescence; Alcohol dehydrogenase isoenzymes; endometrial cancer; alcohol metabolism; aldehyde dehydrogenase
• ISSN: 1791-7530

The aim of this study was to investigate the potential role of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as tumor markers for endometrial cancer. Serum samples were obtained from 40 women with endometrial cancer, 52 with myoma uteri and 52 healthy individuals. Class III, IV of ADH and total ADH activity was measured by a photometric method and class I, II ADH and ALDH activity, by a fluorometric method. The total activity of ADH and ADH class I was significantly higher in the serum of patients with endometrial cancer than in healthy individuals and patients with myoma. The diagnostic sensitivity for ADH I was 69%, specificity 77%, positive predictive value and negative predictive value were 75% and 71% respectively. The area under curve for ADH I was 0.682 and for total ADH was 0.623. The results suggest a potential role of ADH I as a marker for endometrial cancer.