Acromegaly: Medical and Surgical Considerations

Acromegaly results from excessive secretion of insulinlike growth factor-1 and growth hormone, which most commonly occurs because of pituitary somatotrophinoma. Diagnostic features of acromegaly include elevated insulinlike growth factor-1 and growth hormone; lesion on brain MRI; and clinically dysm...

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Published inOtolaryngologic clinics of North America Vol. 55; no. 2; pp. 331 - 341
Main Authors Giantini-Larsen, Alexandra M, Uribe-Cardenas, Rafael, Juthani, Rupa Gopalan
Format Journal Article
LanguageEnglish
Published United States 01.04.2022
Subjects
Acromegaly - diagnosis
Acromegaly - etiology
Acromegaly - surgery
Adenoma - surgery
Growth Hormone-Secreting Pituitary Adenoma - complications
Growth Hormone-Secreting Pituitary Adenoma - pathology
Growth Hormone-Secreting Pituitary Adenoma - surgery
Human Growth Hormone
Humans
Pituitary Neoplasms - complications
Pituitary Neoplasms - surgery
Radiosurgery - adverse effects
Radiosurgery - methods
Retrospective Studies
Treatment Outcome
Stereotactic radiosurgery
Transsphenoidal resection
Insulinlike growth factor-1
Remission rates
Acromegaly
Somatotrophinoma
Growth hormone
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Summary:Acromegaly results from excessive secretion of insulinlike growth factor-1 and growth hormone, which most commonly occurs because of pituitary somatotrophinoma. Diagnostic features of acromegaly include elevated insulinlike growth factor-1 and growth hormone; lesion on brain MRI; and clinically dysmorphic features, such as soft tissue swelling, jaw prognathism, and acral overgrowth. Transsphenoidal resection is the primary therapy for individuals with acromegaly, even in the cases where gross total resection is not possible because of parasellar extension and cavernous sinus involvement. For recurrent or persistent disease after resection, systemic medications and stereotactic radiosurgery are used.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1557-8259
DOI:10.1016/j.otc.2021.12.007