G Protein Subunit Beta 3 (GNB3) Variant Is Associated with Biochemical Changes in Brazilian Patients with Hypertension

• Published in: Arquivos brasileiros de cardiologia Vol. 120; no. 12; p. e20230396
• Main Authors: Agostini, Lívia da Cunha, Silva, Nayara Nascimento Toledo, Lopes, Ana Cláudia Faria, Melo, André Sacramento, Bicalho, Luciana Soares Moreira, Almeida, Tamires Cunha, Belo, Vanessa de Almeida, Coura-Vital, Wendel, Teixeira, Luiz Fernando de Medeiros, Lima, Angélica Alves, Silva, Glenda Nicioli da
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil 01.12.2023
• ISSN: 1678-4170; 1678-4170
• DOI: 10.36660/abc.20230396

Central Illustration : G Protein Subunit Beta 3 (GNB3) Variant Is Associated with Biochemical Changes in Brazilian Patients with Hypertension. Genes and their variants associated with environmental factors contribute to the development of the hypertensive phenotype. The G protein beta 3 subunit gene (GNB3) is involved in the intracellular signaling process, and its variants have been related to susceptibility to arterial hypertension. To determine the association of the GNB3 variant (rs5443:C>T) with arterial hypertension, biochemical parameters, age, and obesity in hypertensive and normotensive individuals from Ouro Preto, Minas Gerais, Brazil. The identification of variants was performed by real-time PCR, using the TaqMan® system, in 310 samples (155 hypertensive and 155 normotensive). Biochemical analyses (renal function, lipid profile and glycemia) were performed from the serum using UV/Vis spectrophotometry and ion-selective electrode. A multiple logistic regression model was used to identify factors associated with arterial hypertension. The analysis of continuous variables with normal distribution was performed using the unpaired Student's t test; non-normal data were analyzed using Mann-Whitney. P < 0.05 was considered significant. The rs5443:C>T variant was not associated with arterial hypertension in the evaluated population (p = 0.88). Regarding biochemical measures, the T allele was associated with high levels of triglycerides, glucose and uric acid in hypertensive individuals (p < 0.05). These results show the importance of genetic diagnosis to prevent the causes and consequences of diseases and imply that the GNB3 rs5443:C>T variant may be associated with changes in the biochemical profile in hypertensive individuals.