Diagnostic challenge of biphenotypic sinonasal sarcoma

Sinonasal biphenotypic sarcoma has recently been described and included in the 2017 WHO classification. It is a low-grade sarcoma which is characterized by PAX3 rearrangements. It remains a diagnostic challenge because of its scarcity, and its considerable histologic overlap with other cellular spin...

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Bibliographic Details
Published inAnnales de pathologie Vol. 39; no. 4; p. 297
Main Authors Benzerdjeb, Nazim, Tantot, Juliet, Ameur, Fatima, Philouze, Pierre, Devouassoux-Shisheboran, Mojgan
Format Journal Article
LanguageFrench
Published France 01.08.2019
Subjects
Aged, 80 and over
Female
Humans
Paranasal Sinus Neoplasms - pathology
Sarcoma - pathology
Nasal cavity
Sarcoma
Fosse nasale
Sarcome nasosinusien biphénotypique
Sarcome
PAX3
Sinonasal biphenotypic sarcoma
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Summary:Sinonasal biphenotypic sarcoma has recently been described and included in the 2017 WHO classification. It is a low-grade sarcoma which is characterized by PAX3 rearrangements. It remains a diagnostic challenge because of its scarcity, and its considerable histologic overlap with other cellular spindle cell neoplasms. The histologic features, the immunoprofile and the main differential diagnoses of sinonasal biphenotypic sarcoma are presented through a case.
ISSN:0242-6498
DOI:10.1016/j.annpat.2019.01.005