Increased expression of electron transport chain genes in uterine leiomyoma

The etiology and pathophysiology of uterine leiomyomas, benign smooth muscle tumors of the uterus, are not well understood. To evaluate the role of mitochondria in uterine leiomyoma, we compared electron transport gene expressions of uterine leiomyoma tissue with myometrium tissue in six uterine lei...

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Bibliographic Details
Published inAnnals of clinical and laboratory science Vol. 44; no. 4; pp. 466 - 468
Main Authors Tuncal, Akile, Aydin, Hikmet Hakan, Askar, Niyazi, Ozkaya, Ali Burak, Ergenoglu, Ahmet Mete, Yeniel, Ahmet Ozgur, Akdemir, Ali, Ak, Handan
Format Journal Article
LanguageEnglish
Published United States 2014
Subjects
Adult
Female
Humans
Leiomyoma - genetics
Leiomyoma - metabolism
Leiomyoma - pathology
Middle Aged
Mitochondrial Proton-Translocating ATPases - genetics
Mitochondrial Proton-Translocating ATPases - metabolism
Myometrium - pathology
RNA, Messenger - metabolism
Leiomyoma
Uterine Fibroid
Mitochondria
Electron Transport System
Oxidative Phosphorylation
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Summary:The etiology and pathophysiology of uterine leiomyomas, benign smooth muscle tumors of the uterus, are not well understood. To evaluate the role of mitochondria in uterine leiomyoma, we compared electron transport gene expressions of uterine leiomyoma tissue with myometrium tissue in six uterine leiomyoma patients by RT-PCR array. Our results showed an average of 1.562 (±0.445) fold increase in nuclear-encoded electron transport genes. These results might suggest an increase in size, number, or activity of mitochondria in uterine leiomyoma that, to our knowledge, has not been previously reported.
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ISSN:1550-8080