Impact of aortic stiffness on the frequency of paroxysmal atrial fibrillation recurrences

• Published in: Acta cardiologica Vol. 70; no. 4; p. 414
• Main Authors: Kizilirmak, Filiz, Guler, Gamze Babur, Guler, Ekrem, Gunes, Haci Murat, Demir, Gultekin Gunhan, Omaygenc, Mehmet Onur, Cakal, Beytullah, Olgun, Fatih Erkam, Koklu, Erkan, Kilicaslan, Fethi
• Format: Journal Article
• Language: English
• Published: England 01.08.2015
• Subjects: Aged; Arterial Pressure; Atrial Fibrillation - diagnosis; Atrial Fibrillation - epidemiology; Atrial Fibrillation - etiology; Atrial Fibrillation - physiopathology; Atrial Fibrillation - therapy; Catheter Ablation - adverse effects; Catheter Ablation - methods; Female; Follow-Up Studies; Heart Atria - pathology; Humans; Incidence; Male; Middle Aged; Organ Size; Prognosis; Pulse Wave Analysis - methods; Recurrence; Risk Factors; Turkey - epidemiology; Vascular Stiffness; Turkey
• ISSN: 0001-5385
• DOI: 10.1080/ac.70.4.3094650

The relationship between arterial stiffness (AS) and atrial fibrillation (AF) incidence is well-known. In this study we aimed to investigate the relationship between AS parameters and AF occurence as well as AF recurrence post catheter ablation (CA) in patients with paroxysmal AF (PAF). We enrolled 103 patients with PAF diagnosis and 103 control subjects with similar demographic characteristics. We measured AS parameters and central aortic pressure (CAP) parameters by an oscillometric device in both groups. In the patient group 51 patients underwent CA for AF and recurrence rates at 3 and 6 months postprocedurally were recorded. AS parameters were compared between patients with and without AF recurrence. In the PAF patient group central systolic pressure, central diastolic pressure, central pulse pressure, augmentation pressure, augmentation index, and pulse wave velocity were significantly higher than in the control group (for each listed parameter P<0.05). AS parameters were not associated with AF recurrence post CA. Left atrial size (LAS) was found as an independent predictor for recurrence in multivariate analysis (0: 2.30; P = 0.02; OR: 9.97; 95% CI [1.28-77.48]). Increased AS is associated with PAF occurence. Nevertheless, LAS, a traditional risk factor, was the most powerful predictor for recurrence post CA; whereas AS or CAP were not associated with recurrence.