The prognostic role of Bcl-2, Ki67, c-MYC and p53 in diffuse large B-cell lymphoma

• Published in: Romanian journal of morphology and embryology Vol. 58; no. 3; pp. 837 - 843
• Main Authors: Pătraşcu, Ana Maria, Rotaru, Ionela, Olar, Lavinia, Pătraşcu, Ştefan, Ghiluşi, Mirela Corina, NeamŢu, Simona Daniela, Nacea, Janina Georgiana, Gluhovschi, Adrian
• Format: Journal Article
• Language: English
• Published: Romania 2017
• Subjects: Humans; Immunohistochemistry - methods; Ki-67 Antigen - metabolism; Lymphoma, Large B-Cell, Diffuse - genetics; Lymphoma, Large B-Cell, Diffuse - metabolism; Lymphoma, Large B-Cell, Diffuse - pathology; Male; Prognosis; Proto-Oncogene Proteins c-bcl-2 - metabolism; Retrospective Studies; Tumor Suppressor Protein p53 - metabolism
• ISSN: 1220-0522

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of lymphoid malignancies, which counts for more than a third of non-Hodgkin's lymphoma cases. The aim of the current study is to evaluate the prognostic role of several immunohistochemical (IHC) markers involved in the pathological process of DLBCL. This is a retrospective analysis of the 97 de novo DLBCL patients admitted between January 2007 and December 2016 in the Department of Hematology, "Filantropia" Municipal Hospital, Craiova, Romania. The expression of Bcl-2, Ki67, c-MYC and p53 was assessed by immunohistochemistry. A significant level of association was observed between high prognostic index values and Bcl-2, Ki67, c-MYC and p53 positive cases. Moreover, overall survival and disease-free survival were higher in patients with negative expression for these markers. Bcl-2, Ki67, c-MYC and p53 could make important diagnostic and therapeutic targets; therefore, their routine assessment should be mandatory.