Indoleamine 2,3‐dioxygenase in intestinal immunity and inflammation

Indoleamine 2,3‐dioxygenase (IDO) is a tryptophan catabolizing enzyme that has a number of immunoregulatory effects. It is expressed at high levels in the gastrointestinal tract, particularly in the small intestine, and has been implicated in the control of intestinal inflammation. However, its prec...

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Bibliographic Details
Published inInflammatory bowel diseases Vol. 15; no. 9; pp. 1391 - 1396
Main Author Cherayil, Bobby J.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2009
Subjects
Enteritis - enzymology
Humans
Immunity
Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology
inflammation in IBD
Intestinal Mucosa - immunology
Intestine, Small - enzymology
mucosal immunology
T-Lymphocyte Subsets - immunology
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Summary:Indoleamine 2,3‐dioxygenase (IDO) is a tryptophan catabolizing enzyme that has a number of immunoregulatory effects. It is expressed at high levels in the gastrointestinal tract, particularly in the small intestine, and has been implicated in the control of intestinal inflammation. However, its precise role in intestinal immunity is not well understood. This review will summarize the current state of knowledge about IDO function, particularly as it pertains to inflammatory responses in the gut. (Inflamm Bowel Dis 2009)
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ISSN:1078-0998
1536-4844
DOI:10.1002/ibd.20910