Markers of redox imbalance in the blood of hypertensive patients of a community in Northeastern Brazil

• Published in: Arquivos brasileiros de cardiologia Vol. 97; no. 2; pp. 141 - 147
• Main Authors: Vasconcelos, Sandra Mary Lima, Goulart, Marília Oliveira Fonseca, Silva, Maria Alayde Mendonça da, Manfredini, Vanusa, Benfato, Mara da Silveira, Rabelo, Luiza Antas, Fontes, Gilberto
• Format: Journal Article
• Language: English; Portuguese; Spanish
• Published: Brazil 01.08.2011
• Subjects: Antihypertensive Agents - therapeutic use; Antioxidants - analysis; Antioxidants - metabolism; Biomarkers - blood; Brazil; Catalase - blood; Epidemiologic Methods; Female; Glutathione - blood; Humans; Hypertension - blood; Hypertension - drug therapy; Male; Malondialdehyde - blood; Middle Aged; Oxidation-Reduction; Oxidative Stress - drug effects; Oxidative Stress - physiology; Brazil
• ISSN: 1678-4170

Recent studies describe the participation of reactive oxygen and nitrogen species in hypertension. To identify the redox imbalance in the blood of hypertensive. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), vitamin C, transferrin, ceruloplasmin, malondialdehyde (MDA) and carbonyl group were quantified in the blood of 20 hypertensives and 21 controls. The individuals had a Body Mass Index of ≥ 18.5 and ≤ 30 kg/m(2), glycemia ≤ 100 mg/dL, serum cholesterol ≤ 200 mg/dL, and were nonsmokers, non-pregnant and non-lactating women, non-users of alopurinol and probucol, with hypertensives on antihypertensive medication. All individuals underwent a preparatory period of 4 weeks without alcohol, vitamin supplements, dexamethasone and paracetamol. Reduced levels of CAT (p 0.013), GSH (p 0.003) and MDA (p 0.014), and high levels of GPx (p 0.001) and ceruloplasmin (p 0.015) were obtained in the hypertensive group compared with controls. A positive correlation between systolic pressure and MDA in hypertensive and diastolic pressure and CAT in controls was obtained. The data obtained suggest that the hypertensives were in redox imbalance, despite the possibly attenuating effect of their antihypertensive medication.