Monitoring the circulation of rotavirus among children after the introduction of the Rotarix™ vaccine in Goiânia, Brazil

The epidemiological features of rotavirus A (RVA) infection differ between children from developing and developed countries which could result in differences in vaccine efficacy around the world. To evaluate the impact of Rotarix™ on RVA prevalence, we monitored RVA genotypes circulating in Goiânia...

Full description

Saved in:
Bibliographic Details
Published inMemórias do Instituto Oswaldo Cruz Vol. 106; no. 4; pp. 499 - 501
Main Authors Borges, Ana Maria Tavares, Dias e Souza, Menira, Fiaccadori, Fabíola Souza, Cardoso, Divina das Dores de Paula
Format Journal Article
LanguageEnglish
Published Brazil 01.06.2011
Subjects
Brazil
Child
Diarrhea - virology
Electrophoresis, Polyacrylamide Gel
Feces - virology
Female
Genotype
Humans
Male
Prevalence
Rotavirus - genetics
Rotavirus - isolation & purification
Rotavirus Infections - prevention & control
Rotavirus Infections - virology
Rotavirus Vaccines - administration & dosage
Vaccines, Attenuated - administration & dosage
Brazil
Online AccessGet full text

Cover

More Information
Summary:The epidemiological features of rotavirus A (RVA) infection differ between children from developing and developed countries which could result in differences in vaccine efficacy around the world. To evaluate the impact of Rotarix™ on RVA prevalence, we monitored RVA genotypes circulating in Goiânia by monitoring virus in faecal samples from children that had or had not been previously vaccinated. From February-November of 2008, 220 faecal samples were collected from children in seven day-care centres. RVA detection was performed by two methodologies and the results were confirmed by polyacrylamide gel electrophoresis. From the 220 samples, eight were RVA-positive (3.6%) and five were from children that had received either one or two doses of the vaccine. All positive samples were collected from children with diarrhoea during August and September. Genotyping of the RVA characterised five of the viral samples as genotype G2P[4] and one as G8P[4], suggesting that G2P[4] was the predominant circulating genotype in Goiânia during the study. The fact that vaccinated children were also infected by RVA suggests that the vaccine does not fully protect against infection by the G2[P4] RVA genotype.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1678-8060
DOI:10.1590/S0074-02762011000400018